Dimethyl Sulfate → N-(7-methoxynaphthalen-1-yl)acetamide

HRID 863505

반응식

HRID 863505 반응식
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([OH:15])[CH:11]=[CH:10]2)(=[O:3])[CH3:2].S(OC)(O[CH3:20])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([O:15][CH3:20])[CH:11]=[CH:10]2)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 809461-Acetamido-7-naphthol

생성물 1

HCID 11447230N-(7-methoxynaphthalen-1-yl)acetamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 8-Acetamido-2-naphthol (21 g, 0.104 mol), dimethyl sulfate (15.1 g, 0.12 mol) and potassium carbonate (41 g, 0.3 mol) in acetone (200 mL) was stirred at room temperature for 48 h. Solids were removed by filtration and washed with methanol, and the filtrate evaporated. The residue was washed in 1:1 hexane:toluene, collected by filtration and dried (24.7 g).

후처리

  1. customSolids were removed by filtration
  2. washwashed with methanol
  3. customthe filtrate evaporated
  4. washThe residue was washed in 1:1 hexane
  5. filtrationtoluene, collected by filtration
  6. customdried (24.7 g)

출처 및 근거

ORD 기록
ord-6af2e0d4890a4fea8e82f0200997e77e
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05721234

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