Hydrochloric Acid → Diethyl 5-amino-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

HRID 864936

반응식

HRID 864936 반응식
Cl.C([NH:5][C:6]1[C:11](=[O:12])[NH:10][C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:8]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:7]=1)(=O)C>C(O)C>[NH2:5][C:6]1[C:11](=[O:12])[NH:10][C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:8]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 19958266Diethyl 5-acetamido-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

생성물 1

HCID 19958246Diethyl 5-amino-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydrogen chloride gas is bubbled into a solution of diethyl 5-acetamido-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate (5.2 g, 0.018 mol) dissolved in absolute ethanol (400 mL) until the solution is saturated at 20° C. The reaction is stirred at room temperature overnight and is then concentrated in vacuo. The resulting residue is dissolved in water, neutralized with solid sodium bicarbonate, and extracted into methylene chloride. The combined organic extracts are dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give diethyl 5-amino-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate as a yellow solid in quantitative yield.

후처리

  1. customis saturated at 20° C
  2. concentrationis then concentrated in vacuo
  3. dissolutionThe resulting residue is dissolved in water
  4. extractionextracted into methylene chloride
  5. dry with materialThe combined organic extracts are dried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8096c5a6258e40e19a9e896d27dfa6b4
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05565412

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