Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine
반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][Cl:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.
후처리
- customThe mixture was evaporated
- dissolutionthe residue was dissolved in water
출처 및 근거
- ORD 기록
- ord-1537debbdfcd4c9fb2d97af472b6fc7c
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723444
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