Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine

HRID 865

반응식

HRID 865 반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][Cl:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 5176654(1-Benzylpyrrolidin-3-yl)methanol

생성물 1

HCID 123645181-Benzyl-3-(chloromethyl)pyrrolidine

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.

후처리

  1. customThe mixture was evaporated
  2. dissolutionthe residue was dissolved in water

출처 및 근거

ORD 기록
ord-1537debbdfcd4c9fb2d97af472b6fc7c
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723444

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