Water → N-ethyl-4-fluoroaniline

HRID 865928노트

반응식

HRID 865928 반응식
I[CH2:2][CH3:3].[F:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:2]([NH:9][C:8]1[CH:10]=[CH:11][C:5]([F:4])=[CH:6][CH:7]=1)[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 6340IodoethaneHCID 97314-FluoroanilineHCID 11430Potassium Carbonate

생성물 1

HCID 4962184N-ethyl-4-fluoroaniline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Iodoethane (3.6 ml) was added to a mixture of 4-fluoroaniline (4.26 ml) and potassium carbonate (6.9 g) in dry DMF (100 ml). After 18.5 h at 23°, the resulting suspension was poured into water (400 ml) and extracted with EA (400 ml). The organic extract was washed with water (200 ml) then saturated brine (200 ml), dried and evaporated. The residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent to give the title compound (3.667 g) as a yellow oil.

후처리

  1. extractionextracted with EA (400 ml)
  2. extractionThe organic extract
  3. washwas washed with water (200 ml)
  4. dry with materialsaturated brine (200 ml), dried
  5. customevaporated
  6. customThe residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent

출처 및 근거

ORD 기록
ord-f3ee23012faf4bc980a61779569cdba7
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569654

반응 노트

불러오는 중…