Hydrogen Bromide → 2-(Bromomethyl)-1,3-dimethoxybenzene

HRID 866057

반응식

HRID 866057 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH2:11]O.[Cl-].[Na+].[BrH:15]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH2:11][Br:15]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 5234Sodium ChlorideHCID 2776839(2,6-Dimethoxyphenyl)methanol

생성물 1

HCID 155569582-(Bromomethyl)-1,3-dimethoxybenzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

After a mixture of 5.7 grams (0.034 mole) of 2,6-dimethoxyphenylmethanol in 40 mL of concentrated hydrobromic acid was stirred at ambient temperature for about one hour, the reaction mixture was taken up in diethyl ether. Solid sodium chloride was added to the mixture to obtain a phase separation. The organic layer was separated and concentrated under reduced pressure, yielding about 4.7 grams of 2,6-dimethoxyphenylmethyl bromide. This compound was used immediately in the next reaction.

후처리

  1. customto obtain
  2. customa phase separation
  3. customThe organic layer was separated
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7323ba6f5da0405a87601d1bbdbdb171
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569664

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