Quipazine → 8-[3-(4-Quinolin-2-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione

HRID 868554

반응식

HRID 868554 반응식
Br[CH2:2][CH2:3][CH2:4][O:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[N:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.C(N(C(C)C)CC)(C)C>CC#N>[N:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:30][CH2:29]1

참가 물질

5

반응물 3

HCID 5011QuipazineHCID 81531DiisopropylethylamineHCID 142805838-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione

생성물 1

HCID 142805948-[3-(4-Quinolin-2-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (5.7 g), 1-(2-quinolinyl)piperazine (4.0 g) and diisopropylethylamine (6.6 ml) in 100 ml of dry CH3CN was heated to 80° with stirring under N2.

후처리

  1. temperaturewas heated to 80°

출처 및 근거

ORD 기록
ord-f72222369e624ba7bdf606f5901df12b
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780466

연결된 노트

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