Benzaldehyde → Syn-benzaldehyde oxime

HRID 868922

반응식

HRID 868922 반응식
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][OH:10].Cl.[OH-].[Na+]>C(O)C.O>[CH:1](=[N:9]/[OH:10])/[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 240BenzaldehydeHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 5324470Syn-benzaldehyde oxime

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a stirred solution of benzaldehyde (3 g, 28.3 mmol) in ethanol (50 mL) and water (30 mL), NH2OH hydrochloride (3.9 g, 56.6 mmol) and sodium hydroxide (2.26 g, 56.6 mmol) were added. The mixture was heated at reflux for 6 hours. The resulting mixture was cooled to room temperature and extracted with EtOAc, and the organic layer was dried over anhydrous sodium sulfate. The solution was then concentrated under vacuum to give the title compound as an oil-like solid (3.4 g), which was used in the next step without further purification. MS (ESI) m/z 121 (M+H+).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 6 hours
  3. extractionextracted with EtOAc
  4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  5. concentrationThe solution was then concentrated under vacuum

출처 및 근거

ORD 기록
ord-f19df7ebeba944b88fc980f07852d648
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969349B2

연결된 노트

불러오는 중…