Ethyl formate → Ethyl 2-(benzyloxy)-3-oxopropanoate

HRID 869301

반응식

HRID 869301 반응식
[H-].[Na+].[CH:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:8]([O:15][CH2:16][C:17](OCC)=[O:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOCC>[CH2:8]([O:15][CH:16]([CH:17]=[O:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 290299Ethyl 2-(benzyloxy)acetate

생성물 1

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a suspension of sodium hydride (3.3 g, 60% in paraffin oil, 82.5 mmol) in dry ether (100 mL) and dry ethyl formate (5.55 g, 75 mmol) was added ethyl (benzyloxy)acetate (14.57 g, 75 mmol) dropwise with stirring. The resulting mixture solution was then refluxed for 2 h and concentrated to give crude ethyl 2-(benzyloxy)-3-oxopropanoate which was used in the subsequent step without further purification.

후처리

  1. temperatureThe resulting mixture solution was then refluxed for 2 h
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bf3ba2740770454b819b381849387ac0
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969364B2

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