Sodium Hydroxide → HCID 136348391, 화합물

HRID 869402노트

반응식

HRID 869402 반응식
[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([OH:11])[C:3]=1[CH:4]=O.Cl.[NH2:13][OH:14].[OH-].[Na+]>CCO>[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([OH:11])[C:3]=1[CH:4]=[N:13][OH:14]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 156059702-Bromo-3,6-dihydroxybenzaldehyde

생성물 1

HCID 136348391HCID 136348391, 화합물수율 84.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of 2-bromo-3,6-dihydroxy-benzaldehyde (12A) (50 g, 0.23 mol) and hydroxylamine hydrochloride (19.2 g, 0.28 mol) was added 95% EtOH (500 mL), followed by NaOH (13.8 g, 0.345 mol). The reaction mixture was stirred at room temperature for 2 hours, then extracted with ethyl acetate and concentrated to give 2-bromo-3,6-dihydroxy-benzaldehyde oxime (12B) (45 g, 84.1% yield) as a solid.

후처리

  1. extractionextracted with ethyl acetate
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-670e5e37d68044959b9b8a514109aa0e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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