Water → 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine

HRID 8699

반응식

HRID 8699 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12](O)[N:11]=[C:10]([CH3:15])[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:18])=O.O>C(#N)C>[Cl:18][C:12]1[CH:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[N:9]=[C:10]([CH3:15])[N:11]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24813Phosphorus oxychlorideHCID 178418772HCID 178418772, 화합물

생성물 1

HCID 158701424-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine수율 97%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

13.8 kg of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine and 11.5 kg of phosphorus oxychloride were refluxed in acetonitrile, and stirred for 4 hours. The reaction solution was combined with water, and the precipitated crystal was separated, and the resultant crystal was washed and dried to obtain 14.6 kg of the target compound as a pale yellow crystal.

후처리

  1. customthe precipitated crystal was separated
  2. washthe resultant crystal was washed
  3. customdried

출처 및 근거

ORD 기록
ord-566f636694d74e4bbcaca894597ef315
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091206B2

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