Iodoethane → 2-Bromophenetole

HRID 870466

반응식

HRID 870466 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].I[CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 72442-BromophenolHCID 11430Potassium Carbonate

생성물 1

HCID 685002-Bromophenetole수율 95.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Into a 500-mL round-bottom flask was placed CH3COCH3 (200 mL), 2-bromophenol (10.38 g, 60.00 mmol, 1.00 equiv), iodoethane (28.08 g, 180.04 mmol, 3.00 equiv) and potassium carbonate (33.12 g, 239.64 mmol, 3.99 equiv). The resulting solution was heated to reflux overnight in an oil bath. The solids were filtered out. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). Purification afforded 11.48 g (95%) of 1-bromo-2-ethoxybenzene as a colorless oil.

후처리

  1. customInto a 500-mL round-bottom flask was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. filtrationThe solids were filtered out
  5. concentrationThe filtrate was concentrated under vacuum
  6. customPurification

출처 및 근거

ORD 기록
ord-c41bb86b516b4a38ad60daf8e2dc2224
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969557B2

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