Hydrochloric Acid → 5-(1H-imidazol-1-yl)pentanoic acid

HRID 870577노트

반응식

HRID 870577 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=[O:11])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Li+].Cl>O1CCCC1.O>[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54266609Methyl 5-imidazol-1-ylpentanoate

생성물 1

HCID 128033135-(1H-imidazol-1-yl)pentanoic acid수율 130.1%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Stir a solution of methyl 5-imidazol-1-ylpentanoate (0.60 g; 1.0 equiv; 3.29 mmoles) and lithium hydroxide (0.553 g; 4 equiv; 13.17 mmoles) in tetrahydrofuran (20 mL) and water (15 mL) for 18 hours. Add 3 ml of 5N hydrochloric acid then concentrate the mixture. Purify the crude product by column chromatography (0 to 15% methanol in dichloromethane) to afford 5-imidazol-1-ylpentanoic acid (0.72 g; 19%) as a yellow oil: MS (m/z): 169(M+1).

후처리

  1. concentrationthen concentrate the mixture
  2. customPurify the crude product by column chromatography (0 to 15% methanol in dichloromethane)

출처 및 근거

ORD 기록
ord-f266ef17be58499186ba1259e1867ca5
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969555B2

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