Hydrochloric Acid → 4-(2H-triazol-4-yloxy)butanoic acid
반응식
[OH-].[Na+].[N:3]1[NH:4][N:5]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[CH:7]=1.Cl>C(O)C>[N:3]1[NH:4][N:5]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:7]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
Add 1N sodium hydroxide (2.32 mL; 2.0 equiv; 2.32 mmoles) to a solution of methyl 4-(2H-triazol-4-yloxy)butanoate (0.215 g; 1.0 equiv; 1.16 mmoles) in ethanol (1 mL) and heat the mixture to 60° C. for 16 hours. Add 1N hydrochloric acid (2.32 mL; 2.0 equiv; 2.32 mmoles) and concentrate to afford 4-(2H-triazol-4-yloxy)butanoic acid (0.20 g; 100%). Use without further purification in the next step: MS (m/z): 170(M−1).
후처리
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-22cbbcf9c8a9473da21557204933a111
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969555B2
반응 노트
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