Water → 4-Methoxyphenyl benzoate

HRID 871977노트

반응식

HRID 871977 반응식
O[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(Cl)(Cl)Cl.[OH2:30]>ClCCl>[C:17]([O:24][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1)(=[O:30])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

7

반응물 5

HCID 962WaterHCID 6212ChloroformHCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 90154-Methoxyphenol

생성물 1

HCID 1370594-Methoxyphenyl benzoate수율 98%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Hydroxyanisole (1.25 g, 10.1 mmol) was dissolved in anhydrous dichloromethane (10 mL), and triethylamine (4.25 mL, 30.5 mmol) and benzoyl chloride (1.40 mL, 12.1 mmol) were added thereto successively. The reaction mixture was stirred at room temperature for 4 hours. Chloroform (50 mL) and water (50 mL) were added to the reaction mixture and partitioned. The organic layer was washed with saturated brine (50 mL), dried over anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. The obtained residue was filtered with hexane (50 mL) to give the titled reference compound (2.24 g) as a colorless solid. (Yield 98%)

후처리

  1. custompartitioned
  2. washThe organic layer was washed with saturated brine (50 mL)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was removed under reduced pressure
  5. filtrationThe obtained residue was filtered with hexane (50 mL)

출처 및 근거

ORD 기록
ord-7cf3ef4c7ffa436893aae22bd0b3e67f
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975256B2

반응 노트

불러오는 중…