Hydrochloric Acid → 2-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

HRID 874403노트

반응식

HRID 874403 반응식
[ClH:1].Cl.[C:3]1([C:9]2[N:10]=[C:11]3[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][N:12]3[CH:18]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H]>[Pt](=O)=O.CO>[ClH:1].[C:3]1([C:9]2[N:10]=[C:11]3[CH2:16][CH:15]([NH2:17])[CH2:14][CH2:13][N:12]3[CH:18]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 117776411HCID 117776411, 화합물HCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 1055088122-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-amine hydrochloride

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매2회HCID 887Methanol용매

실험 절차

Concentrated hydrochloric acid (0.11 ml) and platinum(IV) dioxide (83 mg) were added to a methanol (183 ml) solution of 2-phenylimidazo[1,2-a]pyridin-7-amine hydrochloride (900 mg), and the obtained mixture was then stirred in a hydrogen atmosphere for 4 hours. Thereafter, platinum(IV) dioxide (83 mg) was added to the reaction solution, and the obtained mixture was further stirred in a hydrogen atmosphere for 14 hours 30 minutes. Thereafter, the reaction solution was filtered with Celite, and was then washed with methanol (15 ml). The filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml) was then added to the obtained residue to solidify it, so as to obtain the title compound (733 mg) in the form of a gray solid.

후처리

  1. filtrationThereafter, the reaction solution was filtered with Celite
  2. washwas then washed with methanol (15 ml)
  3. concentrationThe filtrate was concentrated under reduced pressure, and diethyl ether (3.6 ml)
  4. additionwas then added to the obtained residue

출처 및 근거

ORD 기록
ord-fd57c2aef72b40f1b3a04863d1b5b637
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980889B2

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