Hydrochloric Acid → Thieno[3,2-c]pyridine-2-carboxylic acid

HRID 876769노트

반응식

HRID 876769 반응식
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([O:12]C)=[O:11].O[Li].O.Cl>CO.O>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=[O:11]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

생성물 1

HCID 13580293Thieno[3,2-c]pyridine-2-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (12 g, 62.1 mmol) in MeOH (150 mL) and H2O (15 mL) was added LiOH.H2O (5.2 g, 124.2 mmol). The solution was stirred at room temperature overnight, and then acidified with 1N aqueous HCl. The resulting white precipitate was collected by filtration and air-dried to afford the title compound. MS (m/z): 179 (M)+.

후처리

  1. filtrationThe resulting white precipitate was collected by filtration
  2. customair-dried

출처 및 근거

ORD 기록
ord-90be16a73ab14217a01601673cc6a8d7
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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