Diisopropylethylamine → HCID 60197099, 화합물

HRID 877969

반응식

HRID 877969 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[CH3:12][NH:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26].CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([N:13]([CH3:12])[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26])=[O:6]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 27365483-Chloro-4-fluorobenzoyl ChlorideHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

생성물 1

HCID 60197099HCID 60197099, 화합물수율 29%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Chloro-4-fluorobenzoyl chloride (60 mg, 0.31 mmol, CAS RN 65055-17-6) was added to a solution of methyl-(4-o-tolyl-pyridin-3-yl)-amine (45 mg, 0.23 mmol, example 1, intermediate a) and DIPEA (79 μL, 0.45 mmol) in CH2Cl2 (1 mL). The reaction mixture was stirred overnight and then loaded directly onto a silica gel column and eluted with 50% EtOAc in n-hexane to yield the product as a waxy solid (23 mg, 29%). MS (ESI): m/z=355.0 [M+H]+.

후처리

  1. washeluted with 50% EtOAc in n-hexane

출처 및 근거

ORD 기록
ord-3d1e2f56dcde4ff895a1a1fa88d547c7
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987307B2

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