(2-Nitrophenyl)hydrazine → HCID 178517309, 화합물

HRID 878791

반응식

HRID 878791 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][S:8]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=O)(=[O:10])=[O:9].[N+:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][NH2:32])([O-:24])=[O:23]>Cl.C(O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][S:8]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=[N:32][NH:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[N+:22]([O-:24])=[O:23])(=[O:10])=[O:9]

참가 물질

5

반응물 2

HCID 3314739(2-Nitrophenyl)hydrazineHCID 59763031HCID 59763031, 화합물

생성물 1

HCID 178517309HCID 178517309, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 702Ethanol용매

반응 조건

온도
120 °C

실험 절차

A mixture of rpm161 (0.040 g, 0.114 mmol) 2-nitrophenylhydrazine (0.021 g, 0.126 mmol, 1.1 eq) and HCl (aq 4 M, 2 drops) in ethanol (3 mL) was heated in the CEM microwave at 120° C. for 15 min. After cooling to room temperature, pure product rpm168 was collected as an orange precipitate by filtration and dried in vacuo. The pure compound rpm168 was obtained without further purification (0.048 g, 0.099 mmol, 86%). MS (API-ES): m/z 459 (M+NH4)+; HRMS (API-ES) m/z Found: 459.1082 (M+NH4)+.

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationwas collected as an orange precipitate by filtration
  3. customdried in vacuo
  4. customwas obtained without further purification (0.048 g, 0.099 mmol, 86%)

출처 및 근거

ORD 기록
ord-3013d6af1a784f6da467cae0cdc17c3c
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987474B2

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