Sodium Hydroxide → 22276-16-0

HRID 880030

반응식

HRID 880030 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[C:5]#[N:6].Cl.[NH2:12][OH:13].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])/[C:5](=[N:12]/[OH:13])/[NH2:6]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 810513,4-DichlorobenzonitrileHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 1126418522276-16-0

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3,4-dichlorobenzonitrile (2.000 g, 11.63 mmol), hydroxylamine hydrochloride (1.649 mL, 12.79 mmol) and sodium hydroxide (4.15 mL, 12.4 mmol) in ethanol (40 mL) was stirred at rt for 1 h. Concentrated and refluxed in hexane for 30 min and concentrated in vacuo. The product Intermediate 1A was used directly for the next step. HPLC/MS (Method C) RT=1.24 min [M+H]+ 204.9.

후처리

  1. concentrationConcentrated
  2. temperaturerefluxed in hexane for 30 min
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7f9a9f93621a4f90b113d384f20d4f43
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993557B2

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