Dichloromethane → 6-Ethylpyridin-2-amine

HRID 883846

반응식

HRID 883846 반응식
CC1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][CH3:15])[N:9]=2)C(C)=CC=1.Cl.NO.[OH-].[Na+].C(Cl)Cl>CCO.O>[CH2:14]([C:10]1[N:9]=[C:8]([NH2:3])[CH:13]=[CH:12][CH:11]=1)[CH3:15]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 133983042-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-ethylpyridine

생성물 1

HCID 890216-Ethylpyridin-2-amine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

The product from Example 8a (4.93 g, 0.025 mol) was dissolved in a mixture of EtOH (80 mL) and water (30 mL). To this was added hydroxylamine hydrochloride (8.6 g, 0.123 mol) and the resulting mixture heated to 100° C. for 8 h. The reaction mixture was poured into dilute sodium hydroxide solution and the crude product isolated by extraction with CH2Cl2 and dried over MgSO4 filtered and concentrated under vacuum giving the title compound. The material was used as isolated.

후처리

  1. dry with materialdried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-a50a5ac9b3a8470bab5d13c658678c33
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236950B2

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