Phosphorus tribromide → [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester

HRID 885235

반응식

HRID 885235 반응식
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20]O)[CH:7]=1)[CH3:2].P(Br)(Br)[Br:24]>O1CCOCC1>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20][Br:24])[CH:7]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 58237503[3-(4-Bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester

생성물 1

HCID 58237602[3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester수율 75.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To [3-(4-bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.7 g, 1.86 mmol) in 1,4-dioxane (10 mL) was added phosphorus tribromide (0.19 mL, 2.04 mmol), and the reaction was stirred for 1 hour at room temperature. After work-up, 0.6 g of the desired product was obtained.

출처 및 근거

ORD 기록
ord-21b7adda40d34c2cbf5f59cf3b4a9824
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

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