Potassium Cyanide → 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile
반응식
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.C1(C)C=CC(S(O)=O)=CC=1.[Na].[C-:22]#[N:23].[K+]>CS(C)=O.O>[N:5]1[C:4]2[NH:8][CH:9]=[CH:10][C:3]=2[C:2]([C:22]#[N:23])=[N:7][CH:6]=1참가 물질
7
반응 조건
- 온도
- 100 °C
실험 절차
Commercially available 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1 g, 6.51 mmol) was dissolved in DMSO (15 mL) then p-toluenesulfinic acid, sodium salt (1.16 g, 6.51 mmol) and KCN (635 mg, 9.76 mmol) were added. The reaction mixture was heated at 100° C. for 17 h, cooled to RT and diluted with water. The mixture was extracted with EtOAc. The organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo to give 7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile as a light yellow solid.
후처리
- temperaturecooled to RT
- extractionThe mixture was extracted with EtOAc
- washThe organic layers were washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-833c1ae2d1d14930b150fb7ee3264b27
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08247556B2
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