Benzyl Alcohol → 1-(Benzyloxy)-3-bromo-5-chlorobenzene

HRID 888498노트

반응식

HRID 888498 반응식
[Br:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[C:4]([Cl:9])[CH:3]=1.[CH2:10]([OH:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[H-].[Na+].Cl>CN1C(=O)CCC1>[CH2:10]([O:17][C:6]1[CH:5]=[C:4]([Cl:9])[CH:3]=[C:2]([Br:1])[CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 27362231-Bromo-3-chloro-5-fluorobenzene

생성물 1

HCID 532170081-(Benzyloxy)-3-bromo-5-chlorobenzene

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
120 °C

실험 절차

To 1-bromo-3-chloro-5-fluorobenzene (25 g, 112 mmol) and benzyl alcohol (25 mL, 239 mmol) in NMP (200 mL) at room temperature was added sodium hydride (60% in mineral oil; 10.5 g, 263 mmol), and the reaction was heated to 120° C. for 10 hours. The mixture was acidified with 10% aqueous HCl and extracted with EtOAc to give the title compound.

후처리

  1. extractionextracted with EtOAc

출처 및 근거

ORD 기록
ord-fac2c72e136a4636a91b4f91cf675292
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247602B2

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