Hydrochloric Acid → HCID 15219197, 화합물

HRID 889240노트

반응식

HRID 889240 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl.Cl>CCO>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 578349821-(Benzyloxy)-3-fluoro-2-nitrobenzene

생성물 1

HCID 15219197HCID 15219197, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-benzyloxy-3-fluoro-2-nitrobenzene (1.32 g, 5.34 mmol), SnCl2 (4.96 g, 26.2 mmol), and 1N HCl (5.5 mL, 5.5 mmol) in EtOH (25 mL) is refluxed for 18 h. The mixture is concentrated and stirred with EtOAc and 1N NaOH solution. Solid NaOH is added until strongly basic. The precipitate is removed by filtration, and the organic phase is separated. It is then dried and concentrated. The residue is purified to give the title compound: MS (M+H)+=218.

후처리

  1. temperatureis refluxed for 18 h
  2. concentrationThe mixture is concentrated
  3. additionSolid NaOH is added until strongly basic
  4. customThe precipitate is removed by filtration
  5. customthe organic phase is separated
  6. customIt is then dried
  7. concentrationconcentrated
  8. customThe residue is purified

출처 및 근거

ORD 기록
ord-c9200f16d57a49a9be17e27aa34bd76d
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252820B2

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