Potassium Carbonate → HCID 15219197, 화합물

HRID 889279노트

반응식

HRID 889279 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl.C([O-])([O-])=O.[K+].[K+]>CCO.Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 24479Stannous ChlorideHCID 578349821-(Benzyloxy)-3-fluoro-2-nitrobenzene

생성물 1

HCID 15219197HCID 15219197, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

To a solution of 1-benzyloxy-3-fluoro-2-nitrobenzene (10.0 g, 40.5 mmol) in 100 mL of EtOH and 50 mL of 1N HCl is added SnCl2 (38.3 g, 202.5 mmol) and the solution is refluxed for 2 h. After cooling the mixture to RT, it is adjusted to PH>7 with solid K2CO3 and extracted with EtOAc. The organic layer is washed with water and brine, and dried over sodium sulfate. The solvent is removed under reduced pressure to give the product as a yellow liquid.

후처리

  1. temperaturethe solution is refluxed for 2 h
  2. extractionextracted with EtOAc
  3. washThe organic layer is washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-011329f9824a435a98b6edc478f88614
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252820B2

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