Hydrochloric Acid → 6-(4-Chlorophenyl)-1,2,4-triazin-3-one

HRID 889823노트

반응식

HRID 889823 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][NH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O.[Na+].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 31389Sodium 3-nitrobenzenesulfonateHCID 691185446-(4-Chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one

생성물 1

HCID 222487986-(4-Chlorophenyl)-1,2,4-triazin-3-one수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3.64 g (17.4 mmol) of 6-(4-chlorophenyl)-4,5-dihydro-1,2,4-triazin-3-one, 4.0 g of sodium m-nitrobenzene sulfonate (17.8 mmol), 6.0 g of 50% sodium hydroxide (75.2 mmol) and 160 mL of water were refluxed overnight. The reaction mixture was cooled, then 1N aqueous HCl was added until the pH was slightly acidic to paper. The product was filtered, washed with water and dried to give 3.0 g of 6-(4-chlorophenyl)-1,2,4-triazin-3-one, which was used without further purification.

후처리

  1. temperaturewere refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe product was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-9d533606d6fe4d94b682627da06b647e
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995157B2

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