4-Phenylcyclohexanone → 4-Phenylcyclohexanone oxime
반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>C(O)C.O>[OH:16][N:15]=[C:10]1[CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1참가 물질
6
반응 조건
- 온도
- 70 °C
실험 절차
A mixture of 4-phenylcyclohexanone (28.7 mmol), hydroxylamine hydrochloride (36.0 mmol), and sodium acetate (60.95 mmol) in ethanol and water was heated at 70° C. overnight. Ethanol was removed, and the residue was dissolved in water and ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, and concentrated to give 1-(hydroxyimino)-4-phenylcyclohexane (97%).
후처리
- customEthanol was removed
- dissolutionthe residue was dissolved in water
- extractionThe aqueous layer was extracted with ethyl acetate
- washThe combined organic layers were washed with brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d1c6e62fd48849e89adc22db2d64dcf8
- 출처 데이터셋
- uspto-grants-2006_02
- 특허 번호
- US06995269B2
반응 노트
불러오는 중…