Methyl iodide → HCID 86745908, 화합물

HRID 893004노트

반응식

HRID 893004 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:10][CH:11]=[CH2:12])[CH:5]=[C:6]([CH3:9])[C:7]=1[OH:8].[OH-].[K+].I[CH3:16]>CS(C)=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH3:12])[CH:5]=[C:6]([CH3:9])[C:7]=1[O:8][CH3:16]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 124349732,6-Dimethyl-4-(prop-2-en-1-yl)phenol

생성물 1

HCID 86745908HCID 86745908, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

3-(3,5-Dimethyl-4-hydroxyphenyl)-1-propene (5.0 g) is added to a mixture of powdered potassium hydroxide (7.98 g) in dimethylsulfoxide (50 ml) at 15°. Iodomethane (8.8 ) is then added and stirred below 20° for 0.5 hr. The reaction mixture is poured into ice/water and the product is extracted with ether (2×). The ether extracts are washed with water (3×), saline, dried over sodium sulfate and concentrated under reduced pressure to give 3-(3,5-dimethyl-4-methoxyphenyl-1-propene. The "propene" is transformed to the corresponding "propanol" with borane-dimethylsulfide by the general procedure of PREPARATION NA-19 to give the title compound.

후처리

  1. extractionthe product is extracted with ether (2×)
  2. washThe ether extracts are washed with water (3×), saline
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d06ed4b6859f495e9e6ac69d5dc40009
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05120843

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