3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-
반응식
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1참가 물질
4
실험 절차
Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colorless liquid (31.9 g). T.l.c. [L] Rf 0.5.
후처리
- washwashed with H2O (100 ml), aqueous NaHCO3 (1M, 50 ml) and BR (50 ml)
- temperatureThe dried liquid was heated under reduced pressure
출처 및 근거
- ORD 기록
- ord-42cdf4cbd13c4279b3815645c13b7b29
- 출처 데이터셋
- uspto-grants-1992_06
- 특허 번호
- US05126375
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