Hydrochloric Acid → alpha,alpha-Dimethyl-2-naphthaleneethanamine
반응식
[CH3:1][C:2]([NH:15]C(=O)C)([CH3:14])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1.Cl.[OH-].[Na+]>O>[CH3:14][C:2]([NH2:15])([CH3:1])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1참가 물질
5
실험 절차
To N-[2-methyl-1-(naphthalen-2-yl)propan-2-yl]acetamide (26 mg) obtained in Step 8 was added 6N hydrochloric acid (2 ml) and the mixture was heated under reflux for 5 hr. The reaction mixture was poured into water, made basic with a 4N aqueous sodium hydroxide solution, and extracted with diethyl ether. The organic layer was washed with water, dried over potassium carbonate and concentrated under reduced pressure to give the title compound (19 mg).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 5 hr
- extractionextracted with diethyl ether
- washThe organic layer was washed with water
- dry with materialdried over potassium carbonate
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8d1a65d1e9f44f4cb61297243c0c3a2c
- 출처 데이터셋
- uspto-grants-2005_07
- 특허 번호
- US06916956B2
반응 노트
불러오는 중…