Hydrochloric Acid → HCID 22349525, 화합물

HRID 896073노트

반응식

HRID 896073 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[OH:11])=[CH:4][CH:3]=1.N1C(C)=CC=CC=1C.[CH:20]([Si:23](OS(C(F)(F)F)(=O)=O)([CH:27]([CH3:29])[CH3:28])[CH:24]([CH3:26])[CH3:25])([CH3:22])[CH3:21].Cl>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][CH:8]2[O:11][Si:23]([CH:27]([CH3:29])[CH3:28])([CH:24]([CH3:26])[CH3:25])[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 79372,6-LutidineHCID 2724529Triisopropylsilyl trifluoromethanesulfonateHCID 27548246-bromo-2,3-dihydro-1H-inden-1-ol

생성물 1

HCID 22349525HCID 22349525, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 6-Bromo-2,3-dihydro-1H-inden-1-ol (300 mg, 1.41 mmol) in CH2Cl2 (4 mL) was added 2,6-lutidine (151 μL, 1.41 mmol) followed by triisopropylsilyltriflate (378 μL, 1.41 mmol) at room temperature. The reaction was stirred for 30 min then added to 1N HCl and extracted. The organic layer was washed with saturated sodium bicarbonate then brine and dried over MgSO4. The solvent was removed in vacuo and the crude material purified by column chromatography.

후처리

  1. extractionextracted
  2. washThe organic layer was washed with saturated sodium bicarbonate
  3. dry with materialbrine and dried over MgSO4
  4. customThe solvent was removed in vacuo
  5. customthe crude material purified by column chromatography

출처 및 근거

ORD 기록
ord-591e89d93cee4268ba645c7de5d02c94
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919335B2

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