Sodium Hydroxide → 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5 carboxylic acid

HRID 896303노트

반응식

HRID 896303 반응식
[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH2:13][C:14]2[N:18]([CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])[C:17]3[CH:24]=[CH:25][C:26]([C:28]#N)=[CH:27][C:16]=3[N:15]=2)[C:5]1=[O:30])([CH3:3])[CH3:2].[OH-:31].[NH4+].[OH-:33].[Na+]>Cl>[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH2:13][C:14]2[N:18]([CH2:19][CH2:20][CH:21]([CH3:22])[CH3:23])[C:17]3[CH:24]=[CH:25][C:26]([C:28]([OH:33])=[O:31])=[CH:27][C:16]=3[N:15]=2)[C:5]1=[O:30])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 223493242-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carbonitrile

생성물 1

HCID 223493412-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5 carboxylic acid수율 83%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carbonitrile (2.00 g, 5.0 mmol) and 6M HCl (50 mL) was heated to reflux for 12 h. After cooling, the final solution was neutralized by ammonium hydroxide and 1M NaOH to pH 6. The precipitate was collected by filtration and the solid washed with water thoroughly and dried in a vacuum oven to yield 1.74 g (83%) of 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5 carboxylic acid as a white solid.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 12 h
  3. temperatureAfter cooling
  4. filtrationThe precipitate was collected by filtration
  5. washthe solid washed with water thoroughly
  6. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-1716b42f6d964eb691b9cb4356c1f499
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919331B2

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