Tetrahydrofuran → HCID 86142661, 화합물

HRID 897067

반응식

HRID 897067 반응식
[C:1]1([C:7]#[C:8][C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][Si:14]([CH3:18])([CH3:17])[C:15]#[CH:16].[CH2:19]1COCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[C:1]1([C:7]([C:16]#[C:15][Si:14]([CH3:18])([CH3:17])[CH3:13])=[CH:8][C:9]([O:11][CH2:12][CH3:19])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 66111TrimethylsilylacetyleneHCID 138378Phenylpropynoic acid methyl ester

생성물 1

HCID 86142661HCID 86142661, 화합물

시약·촉매·용매 1

HCID 167845palladium(II) acetate촉매

실험 절차

A solution of TDMPP (1.4 g) and palladium acetate (700 mg) in THF (200 ml) is stirred for 15 min at room temperature and methyl phenylpropiolate (10 g, 62.5 mmol) is then added. The reaction medium is stirred for 5 min at room temperature and trimethyl-silylacetylene (87.5 mmol) is then added. Stirring is continued overnight at room temperature. The reaction medium is concentrated and filtered through silica.

후처리

  1. stirringStirring
  2. waitis continued overnight at room temperature
  3. concentrationThe reaction medium is concentrated
  4. filtrationfiltered through silica

출처 및 근거

ORD 기록
ord-61eae75c5d7947aeb1d138ab049b4db4
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921777B2

연결된 노트

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