Triethylamine → N'-hydroxynonanimidamide

HRID 898118

반응식

HRID 898118 반응식
[CH2:1]([C:9]#[N:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl.[NH2:12][OH:13].C(N(CC)CC)C>CCO>[OH:13][NH:12][C:9](=[NH:10])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 16715NonanenitrileHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 5074022N'-hydroxynonanimidamide수율 27%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Octyl cyanide (2 g, 14 mmol) and hydroxylamine hydrochloride (2.495 g, 36 mmol) were dissolved in EtOH (10 mL) and treated with triethylamine (5 mL, 36 mmol) at reflux over night. Extraction: AcOEt/water. Silica gel chromatography: heptane/AcOEt 1:2 afforded a white solid (0.65 g, 26%). MS: m/z=173 (M +H).

후처리

  1. temperatureat reflux over night
  2. extractionExtraction

출처 및 근거

ORD 기록
ord-344e2ede1a55402092f36b2c52f6ed11
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351700B2

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