Carbon tetrabromide → (e)-n-[4-(3-Bromo-propyl)-3-chloro-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

HRID 898555노트

반응식

HRID 898555 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[C:23]([NH:31][C:32](=[O:46])/[CH:33]=[CH:34]/[C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][C:36]=2[Cl:45])[CH:24]=[CH:25][C:26]=1[CH2:27][CH2:28][CH2:29]O.[Br:47]C(Br)(Br)Br>ClCCl>[Br:47][CH2:29][CH2:28][CH2:27][C:26]1[CH:25]=[CH:24][C:23]([NH:31][C:32](=[O:46])/[CH:33]=[CH:34]/[C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][C:36]=2[Cl:45])=[CH:22][C:21]=1[Cl:20]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 68878212(e)-n-[3-Chloro-4-(3-hydroxy-propyl)-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

생성물 1

HCID 87610233(e)-n-[4-(3-Bromo-propyl)-3-chloro-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.577 g (2.200 mmol) triphenylphosphine was added batchwise to a suspension of 0.836 g (2.000 mmol) (E)-N-[3-chloro-4-(3-hydroxy-propyl)-phenyl]-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylamide and 0.730 g (2.200 mmol) tetrabromomethane in 10 mL dichloromethane and the mixture was stirred for 48 h at RT. The reaction mixture was purified by column chromatography (silica gel, dichloromethane) and the residue was triturated with petroleum ether.

후처리

  1. customThe reaction mixture was purified by column chromatography (silica gel, dichloromethane)
  2. customthe residue was triturated with petroleum ether

출처 및 근거

ORD 기록
ord-beab3948de0142909c82ae7a8854c65e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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