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Hydrochloric Acid → 1-(2-{2-Chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-piperidin-4-carboxylic acid

HRID 898598
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HRID 898598 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:23]=[C:22]([NH:24][C:25](=[O:39])[CH2:26][O:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:29]=2[Cl:38])[CH:21]=[CH:20][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]1.Cl>CCO>[Cl:3][C:4]1[CH:23]=[C:22]([NH:24][C:25](=[O:39])[CH2:26][O:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:35])[F:36])=[CH:30][C:29]=2[Cl:38])[CH:21]=[CH:20][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 9985339Ethyl 1-(2-{2-chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-piperidine4-carboxylate

생성물 1

HCID 596916001-(2-{2-Chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-piperidin-4-carboxylic acid

시약·촉매·용매 1

HCID 702
Ethanol
용매

실험 절차

2 mL aqueous NaOH (1 M) was added at RT to a solution of 150 mg (0.270 mmol) ethyl 1-(2-{2-chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-piperidine-4-carboxylate (Example 146) in 4 mL EtOH and the mixture was stirred for 16 h. The reaction mixture was neutralised with 2 mL aqueous HCl (1 M), evaporated down i. vac. and the crude product was purified by column chromatography (silica gel, dichloromethane/MeOH 4:1).

후처리

  1. customevaporated down i
  2. customand the crude product was purified by column chromatography (silica gel, dichloromethane/MeOH 4:1)

출처 및 근거

ORD 기록
ord-974ca5b0083845f9a33c2f2436eb794b
출처 데이터셋
uspto-grants-2008_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07351719B2

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