Hydrochloric Acid → 3,6,9,12,15,18,21-Heptaoxatricosanoic acid, 23,23,23-trifluoro-

HRID 899428노트

반응식

HRID 899428 반응식
[F:1][C:2]([F:30])([F:29])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][C:24]([O:26]CC)=[O:25].Cl>[OH-].[Na+].[Cl-].[Na+].O>[F:1][C:2]([F:29])([F:30])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][C:24]([OH:26])=[O:25]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 17956300HCID 17956300, 화합물

생성물 1

HCID 102737623,6,9,12,15,18,21-Heptaoxatricosanoic acid, 23,23,23-trifluoro-수율 88%

시약·촉매·용매 2

HCID 14798Sodium Hydroxide용매HCID 57417360Sodium chloride; water용매

실험 절차

The product of step (e) (400 mg) was dissolved in an aqueous sodium hydroxide solution (0.1M) (10 ml) and the reaction was stirred at room temperature for 16 hours. The reaction mixture was acidified to pH 2 by the addition of hydrochloric acid (2M), then this was diluted with brine (200 ml) and extracted with dichloromethane (2×200 ml). The combined organic layers were dried and the solvent removed in vacuo to give the title compound as a colourless oil (330 mg).

후처리

  1. extractionextracted with dichloromethane (2×200 ml)
  2. customThe combined organic layers were dried
  3. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-6c11f587751e4f65be609191c3e9a1b3
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07354966B2

반응 노트

불러오는 중…