N-bromobutanimide → 2-Acetylamino-5-bromo-3-cyanothiophene
반응식
[C:1]([NH:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[C:10]#[N:11])(=[O:3])[CH3:2].[Br:12]N1C(=O)CCC1=O>CN(C)C=O>[C:1]([NH:4][C:5]1[S:6][C:7]([Br:12])=[CH:8][C:9]=1[C:10]#[N:11])(=[O:3])[CH3:2]참가 물질
4
실험 절차
2-Acetylamino-3-cyanothiophene (13.5 g) was dissolved in dimethylformamide (110 ml) and cooled in an ice/water bath. N-Bromosuccinimide (15.9 g) was added portion wise over 20 minutes and then the mixture warmed to room temperature and stirred for 3 h. The mixture was concentrated to approximately half the volume and water added to precipitate the product. This was filtered off and dried at 60° C. under vacuum (18.8 g).
후처리
- temperaturecooled in an ice/water bath
- concentrationThe mixture was concentrated to approximately half the volume and water
- additionadded
- customto precipitate the product
- filtrationThis was filtered off
- customdried at 60° C. under vacuum (18.8 g)
출처 및 근거
- ORD 기록
- ord-f0baf2de5c144b1dbe1e459fa3ce055a
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07358376B2
반응 노트
불러오는 중…