methyl 4-nitro-1-phenyl-1H-pyrazole-3-carboxylate → 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid

HRID 902204노트

반응식

HRID 902204 반응식
[N+:1]([C:4]1[C:5]([C:15]([O:17]C)=[O:16])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1)([O-:3])=[O:2]>[OH-].[Na+].Cl>[N+:1]([C:4]1[C:5]([C:15]([OH:17])=[O:16])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1)([O-:3])=[O:2]

참가 물질

4

반응물 1

HCID 23084897methyl 4-nitro-1-phenyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 230849354-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid수율 93.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 14798Sodium Hydroxide용매

실험 절차

Methyl 4-nitro-1-phenyl-1H-pyrazole-3-carboxylate (1.14 g, 4.63 mmol) was suspended in 1N sodium hydroxide (11 mL), and the solution was stirred at room temperature for 2 hours under a nitrogen atmosphere. The precipitates formed upon addition of IN hydrochloric acid (12 mL) were collected by filtration, washed with water and dried to obtain the title compound (1.00 g, 93.2%).

후처리

  1. filtrationwere collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-bc30b223602748ea85491e4e7d58c027
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365079B2

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