Benzylamine → (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione
반응식
[C:1]([OH:10])(=O)[C@@H:2]([C@H:4]([C:6](O)=[O:7])[OH:5])[OH:3].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[CH2:11]([N:18]1[C:6](=[O:7])[C@H:4]([OH:5])[C@@H:2]([OH:3])[C:1]1=[O:10])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
L-Tartaric acid (30 g) and benzylamine (22 ml) were added to xylene (150 ml), and the mixture was heated under reflux at 150° C. for 3 hours using a Dean-Stark trap. After the reaction mixture was allowed to cool overnight, crystals were collected by filtration and washed with acetone. The resultant crude product was recrystallized from ethanol to obtain the title compound (23.2 g).
후처리
- temperaturethe mixture was heated
- temperatureto cool overnight
- filtrationcrystals were collected by filtration
- washwashed with acetone
- customThe resultant crude product was recrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-b92a67768b5145719dccda173d76038a
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07365205B2
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