Hydrochloric Acid → 7-Chloro-10-[(4-diethylaminobutyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride

HRID 903142

반응식

HRID 903142 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](Cl)=[C:7]3[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:8]3=[N:9][C:10]=2[CH:11]=1.[CH2:19]([N:21]([CH2:27][CH3:28])[CH2:22][CH2:23][CH2:24][CH2:25][NH2:26])[CH3:20].C1(O)C=CC=CC=1.[ClH:36]>CC(C)=O.C(O)C>[ClH:1].[ClH:36].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([NH:26][CH2:25][CH2:24][CH2:23][CH2:22][N:21]([CH2:27][CH3:28])[CH2:19][CH3:20])=[C:7]3[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:8]3=[N:9][C:10]=2[CH:11]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 231071-Aza-6,9-dichloro-2-methoxyacridineHCID 117976N,N-Diethyl-1,4-butanediamine

생성물 1

HCID 233378077-Chloro-10-[(4-diethylaminobutyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride

시약·촉매·용매 2

HCID 180Acetone용매HCID 702Ethanol용매

실험 절차

A mixture of 2.8 g. of 7,10-dichloro-2-methoxypyrido[3,2-b]quinoline, 1.5 g. of 4-diethylaminobutylamine and 6.5 g. of phenol is heated at 100° C. for 3 hours. The reaction is cooled, 20 ml. of ethanol is added and this mixture is poured into a mixture of 200 ml. of acetone and 2.5 ml. of concentrated hydrochloric acid. The yellow solic is collected, air-dried and recrystallized from ethanol, giving the desired product, mp. 246°-274° C. (dec.).

후처리

  1. additionA mixture of 2.8 g
  2. temperatureThe reaction is cooled
  3. additionthis mixture is poured into a mixture of 200 ml
  4. customThe yellow solic is collected
  5. customair-dried
  6. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-2c75155f472c454c93c6d225029f2eb2
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04226869

연결된 노트

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