Hydrogen Bromide → 5-((2-Aminoethyl)thiomethyl)thiazole dihydrobromide

HRID 903247노트

반응식

O[CH2:2][C:3]1[S:7][CH:6]=[N:5][CH:4]=1.Cl.[NH2:9][CH2:10][CH2:11][SH:12].CO.[BrH:15]>>[BrH:15].[BrH:15].[NH2:9][CH2:10][CH2:11][S:12][CH2:2][C:3]1[S:7][CH:6]=[N:5][CH:4]=1

참가 물질

반응물 4

HCID 260Hydrogen Bromide

HCID 887Methanol

HCID 9082Cysteamine Hydrochloride

HCID 27632165-Thiazolylmethanol

생성물 1

HCID 205578455-((2-Aminoethyl)thiomethyl)thiazole dihydrobromide

실험 절차

The reaction of 5-hydroxymethylthiazole (2.01 g.) with cysteamine hydrochloride (1.99 g.) in aqueous hydrobromic acid by the method described in Example 1(i)(a) gave 5-[(2-aminoethyl)thiomethyl]thiazole dihydrobromide (4.85 g.), m.p. 191°-194° (from methanol).

출처 및 근거

ORD 기록: ord-dfcf9a44669d47df9b47be312338bfd0
출처 데이터셋: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04226874

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