Ethyl formate → Ethyl 2-formyl-3-(3-methoxyphenyl)propionate

HRID 903356노트

반응식

HRID 903356 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1.[CH:16](OCC)=[O:17].[Na]>CCOCC>[CH:16]([CH:10]([CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:17]

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 584318Ethyl 3-(3-methoxyphenyl)propanoateHCID 5360545Sodium

생성물 1

HCID 10823703Ethyl 2-formyl-3-(3-methoxyphenyl)propionate수율 40.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of ethyl 3-(3-methoxyphenyl)propionate (100 g) and ethyl formate (37 g) was added dropwise to a mixture of sodium wire (11 g) in stirred ether (500 ml) at 0°. The mixture was stirred at room temperature for 16 hours and evaporated to dryness. The residue was dissolved in water and extracted with ether, the extracted aqueous phase was adjusted to pH 4 with hydrochloric acid and was extracted with ether and the ether extract was evaporated to dryness to give ethyl 2-formyl-3-(3-methoxyphenyl)propionate (46.05 g).

후처리

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ether
  4. extractionwas extracted with ether
  5. extractionthe ether extract
  6. customwas evaporated to dryness

출처 및 근거

ORD 기록
ord-6e5f3ef0d4774b8e8b9a4313068ec3b2
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04227000

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