Hydrochloric Acid → 2-Methoxyethylthio-phenylsulfonamide

HRID 904601

반응식

HRID 904601 반응식
[CH3:1][O:2][CH2:3][CH2:4][SH:5].[H-].[Na+].F[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16].Cl>O.CN(C)C=O>[CH3:1][O:2][CH2:3][CH2:4][S:5][NH:18][S:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:9]=1)(=[O:17])=[O:16]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 1936632-FluorobenzenesulfonamideHCID 30146442-Methoxyethanethiol

생성물 1

HCID 569946842-Methoxyethylthio-phenylsulfonamide

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

3.6 of 2-methoxyethyl-mercaptan is added dropwise to a mixture of 3.5 g of 55% sodium hydride and 80 ml of dimethylformamide. To this mixture 8.0 of 2-fluorophenylsulfonamide are added. The reaction mixture is stirred for 3 hours at a temperatur of 115°-120° C. After cooling the mixture is poured into water. To this mixture 10% of hydrochlorid acid are added, and the product is extracted with ethyl acetate. The organic phase is evaporated and the residue is purified by chromatography. Yield: 6.7 g of 2-methoxyethylthio-phenylsulfonamide, m.p. 119°-121° C.

후처리

  1. temperatureAfter cooling the mixture
  2. extractionthe product is extracted with ethyl acetate
  3. customThe organic phase is evaporated
  4. customthe residue is purified by chromatography

출처 및 근거

ORD 기록
ord-46f1f92be4a744a29b4fcb490ebcd61f
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04419121

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