Hydrochloric Acid → 6-(Hydroxymethyl)pyridine-3-carboxylic acid

HRID 905649노트

반응식

HRID 905649 반응식
[OH-].[Na+].C[O:4][C:5]([C:7]1[CH:8]=[N:9][C:10]([CH2:13][O:14]C(=O)C)=[CH:11][CH:12]=1)=[O:6].Cl>CO>[OH:14][CH2:13][C:10]1[N:9]=[CH:8][C:7]([C:5]([OH:6])=[O:4])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10353032Methyl 6-(acetoxymethyl)nicotinate

생성물 1

HCID 147221306-(Hydroxymethyl)pyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Under ice cooling, 2 M aqueous sodium hydroxide solution (3.0 mL) was added to a solution of 6-acetoxymethylpyridine-3-carboxylic acid methyl ester (Reference Compound No. 9-1, 0.60 g, 2.9 mmol) in methanol (6.0 mL). The reaction mixture was stirred under ice cooling for 40 minutes and at room temperature for 4 hours. Under ice cooling, 2 M hydrochloric acid (3.1 mL) was added thereto, and then the solvent was evaporated under reduced pressure to give the title reference compound as an orange solid.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. customto give the title reference compound as an orange solid

출처 및 근거

ORD 기록
ord-a9d9ab3968bc4e2d87db5edab0facf8a
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012972B2

반응 노트

불러오는 중…