Hydrochloric Acid → HCID 57439914, 화합물
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[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[S:13](Cl)(=O)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O.Cl>C1COCC1.C(OCC)(=O)C.CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[SH:13]참가 물질
8
실험 절차
To a solution of 6-bromo-1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride (Example 46a, 1 g) in THF (12 mL) was added triphenylphosphine (2.85 g). After 5 min, water (0.48 mL) was added followed by DMF (0.6 mL) and the reaction stirred for 1 h. Ethyl acetate and 2M HCl (aq) were added and the mixture shaken vigorously. The solid was filtered off and washed with further water and ethyl acetate before drying in vacuo at room temperature is for 2 h to afford the subtitle compound (0.2 g).
후처리
- stirringthe mixture shaken vigorously
- filtrationThe solid was filtered off
- washwashed with further water and ethyl acetate
- custombefore drying in vacuo at room temperature
- waitis for 2 h
출처 및 근거
- ORD 기록
- ord-fd6392823a4747a2bef17464c98e432a
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08012980B2
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