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Hydrochloric Acid → (2-Cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester

HRID 907649
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반응식

HRID 907649 반응식
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:22])([CH3:21])[CH:10]([O:17]C(=O)C)[C:11](=[O:16])[NH:12][CH:13]1[CH2:15][CH2:14]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]([CH3:22])([CH3:21])[CH:10]([C:11](=[O:16])[NH:12][CH:13]1[CH2:15][CH2:14]1)[OH:17])([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67384759Acetic acid 2-tert-butoxycarbonylamino-1-cyclopropylcarbamoyl-2-methylpropyl ester

생성물 1

HCID 67385732(2-Cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of acetic acid 2-tert-butoxycarbonylamino-1-cyclopropylcarbamoyl-2-methylpropyl ester in MeOH (10 mL) was added 10% NaOH (1.5 mL). The reaction mixture was stirred at room temperature for 3 h and then acidified with 1N Hydrochloric acid to pH 7. The reaction mixture was extracted with EtOAc. The organic layer was dried (Na2SO4) concentrated to yield (2-cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester which was used in the next step without further purification.

후처리

  1. extractionThe reaction mixture was extracted with EtOAc
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-79afd4ecbe5b4495a4ea50f3218583b1
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08013183B2

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