Hydrochloric Acid → HCID 58446922, 화합물

HRID 908231노트

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HRID 908231 반응식
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]([CH3:19])[N:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:7])C.Cl.[Na+].[Cl-]>C1COCC1>[N:15]1([C:13]([C:12]2[CH:11]=[N:10][N:9]([CH3:19])[C:8]=2[C:6]([OH:7])=[O:5])=[O:14])[CH2:18][CH2:17][CH2:16]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 67041800ethyl 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylate

생성물 1

HCID 58446922HCID 58446922, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

NaOH (1N, 10 ml) was added to a solution of 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1.32 g, 5.0 mmol) in THF (50 ml), and the mixture was stirred at r.t. (3.5 h). The mixture was neutralized by addition of HCl (1N, 10 ml). The mixture was evaporated under vacuum and the title compound, containing theoretically 2 equiv. of NaCl, (1.72 g, 99%) was used in Step 6 without further purification. MS (m/e)=210.2 [M+H+].

후처리

  1. customThe mixture was evaporated under vacuum

출처 및 근거

ORD 기록
ord-8549ca19a572413c87c2426f9bcb4212
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017604B2

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