Hydrochloric Acid → 4-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid

HRID 910608노트

반응식

HRID 910608 반응식
[OH-].[Na+].[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17]C)=[O:16])=[CH:13][CH:12]=2)=[CH:5]1.Cl>CCO>[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)=[CH:5]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57583987Methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate

생성물 1

HCID 575840694-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid수율 84.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1 M NaOH (1.42 ml) was added to an EtOH suspension (3 ml) of methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate (115 mg), followed by stirring at room temperature for 8 hours. 1 M HCl (1.42 ml) was added to the reaction solution, followed by concentration under reduced pressure. Water (20 ml) was added to the residue, followed by stirring for 20 minutes. The precipitate formed was collected by filtration and dried under reduced pressure at 60° C. to obtain 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid (92 mg).

후처리

  1. concentrationfollowed by concentration under reduced pressure
  2. additionWater (20 ml) was added to the residue
  3. stirringby stirring for 20 minutes
  4. customThe precipitate formed
  5. filtrationwas collected by filtration
  6. customdried under reduced pressure at 60° C.

출처 및 근거

ORD 기록
ord-93825d8b1fd04ca68dd31dbe8ae0f235
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022208B2

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