Sodium hydrosulfide → 2-Chloro-4-(ethylsulfonyl)benzenethiol
반응식
[SH-:1].[Na+].[CH2:3]([S:5]([C:8]1[CH:13]=[CH:12][C:11](F)=[C:10]([Cl:15])[CH:9]=1)(=[O:7])=[O:6])[CH3:4]>CN(C=O)C.[OH-].[Na+]>[Cl:15][C:10]1[CH:9]=[C:8]([S:5]([CH2:3][CH3:4])(=[O:7])=[O:6])[CH:13]=[CH:12][C:11]=1[SH:1]참가 물질
5
실험 절차
Sodium hydrosulphide (0.252 g) was added to the product from example 4 step (i) (11.0 g) in dry DMF (10 ml) and stirred at RT for 2 h. The mixture was diluted with 2M sodium hydroxide solution and extracted with diethylether. The aqueous layer was acidified with 2M hydrochloric acid, extracted with ethyl acetate, dried and evaporated under reduced pressure, crude yield 1.60 g.
후처리
- extractionextracted with diethylether
- extractionextracted with ethyl acetate
- customdried
- customevaporated under reduced pressure, crude yield 1.60 g
출처 및 근거
- ORD 기록
- ord-2c5ad7ee73c7461dbae0cf95dc3459cd
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022248B2
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